“Cockayne syndrome (also called Weber-Cockayne syndrome, or Neill-Dingwall Syndrome) is a rare autosomal recessive congenital disorder characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging. Hearing loss and eye abnormalities (pigmentary retinopathy) are other common features, but problems with any or all of the internal organs are possible. It is associated with a group of disorders called leukodystrophies. The underlying disorder is a defect in a DNA repair mechanism. It is named after English physician Edward Alfred Cockayne (1880–1956)”. – Wikipedia

Photo: Mother of 12-year-old Chinese girl Sun Yangyang suffering from Cockayne syndrome, tends her at the First Affiliated Hospital of Jilin University on November 11, 2006 in Changchun of Jilin Province, China. The disease results in the senile appearance of Yangyang and also causes eyesight, hearing weakness and other problems. Doctors failed to cure the girl... (Photo by China Photos/Getty Images)

American socialite and media personality Kylie Jenner in the second decade of May 2023 gets up close and personal with a selfie. (Photo by kyliejenner/Instagram)

The Soyuz MS-17 spacecraft carrying the crew formed of Kathleen Rubins of NASA, Sergey Ryzhikov and Sergey Kud-Sverchkov of the Russian space agency Roscosmos blasts off to the International Space Station (ISS) from the launchpad at the Baikonur Cosmodrome, Kazakhstan on October 14, 2020. (Photo by Russian space agency Roscosmos/Handout via Reuters)

With their wings at full length, these beautiful golden eagles soar through the skies in a glorious training session to hunt their prey. Others sit on the arms of their owners and trainers. Batzaya Choijiljav, 41, from Mongolia has taken these magnificent pictures at the annual traditional Kazakhs festival, October 2015. (Photo by Batzaya Choijiljav/Caters News)

A dejected German Grenadier carrying a machine gun on his shoulder in front of a building on fire during the German retreat in Russia. (Photo by Keystone/Getty Images). 1944

A girl looks with comic disgust at a guy who falls asleep with a bottle of beer at a party; her friend laughs. (Photo by Edward Corbett/Rex Features/Shutterstock)

“After an afternoon of hiking and exploring the caves of Rhossili Bay, West Glamorgan, we caught the sun breaking through the clouds”. (Photo by Megan Warren-Davis/The Guardian)

Shortlisted images in the running to be crowned Photobox Instagram photograph of the year range from furry friends to the Holi festival to the meaning of love. Judges, including the Guardian’s former picture editor Eamonn McCabe, have whittled down 180,000 submissions to unearth a shortlist that celebrates the best of social media. Winners will be announced October 3, 2018. Here: Najac, France. Travel shortlist. (Photo by Aaron Jenkin/@aaronjenkin)