In the spring of 1965, within weeks of 3,500 American Marines arriving in Vietnam, a 39-year-old Briton named Larry Burrows began work on a feature for LIFE magazine, chronicling the day-to-day experience of U.S. troops on the ground – and in the air – in the midst of the rapidly widening war. The photographs in this gallery focus on a calamitous March 31, 1965, helicopter mission; Burrows’ “report from Da Nang”, featuring his pictures and his personal account of the harrowing operation, was published two weeks later as a now-famous cover story in the April 16, 1965, issue of LIFE.

Photo: Man your battle stations: The crew chief of helicopter Yankee Papa 13, lance corporal James C. Farley, mans an M-60 machine gun during a mission near Da Nang, Vietnam on March 31, 1965. (Photo by Larry Burrows/Time & Life Pictures)

In this October 29, 2013 photo, Daniel smokes marijuana inside his apartment where he uses a hydroponics system to grow his weed in Mexico City. “I'm not a narco, dude. I just like to smoke”, said Daniel, who spoke on condition that his last name not be used because, he said, his home-grow operation is "super-illegal" despite being for personal use only. (Photo by Eduardo Verdugo/AP Photo)

Cardboard cut outs of the faces of three candidates for the Republican nomination for the 2016 US Presidential election (L-R) Ted Cruz, Donald Trump and Marco Rubio, are seen set up on urinals in a pub in London on March 1, 2016 as part of an informal poll for customers to log which they dislike the most. Part of the satirical television show The Last Leg, customers at the pub are able to choose which urinal to use and then log their poll on a list on the wall afterwards. (Photo by Justin Tallis/AFP Photo)

A visitor takes a picture of a display bearing hand prints of war heroes from the War of Resistance against Japan, at Jianchuan Museum Cluster in Anren, Sichuan Province, China, May 13, 2016. Tucked away in southwestern China's Sichuan province, a private collector stands virtually alone in exhibiting relics from the 1966-1976 Cultural Revolution. Monday marks the 50th anniversary of the start of the political movement, with no official commemorations planned. Official records whitewash the details of both periods, but admit that Mao made major mistakes. (Photo by Kim Kyung-Hoon/Reuters)

A hot air balloon in the likeness of Yoda from Star Wars prepares for liftoff at the 21st Philippine International Hot Air Balloon Festival at the former Clark US Air Force base in Pampanga Province, Philippines on February 9, 2017. (Photo by Xinhua News Agency/Rex Features/Shutterstock)

Miss Nord-Pas-de-Calais Camille Cerf (C) is congratulated by Miss Ile de France 2014 Margaux Savary (L) and Miss Auvergne 2014 Morgane Laporte after Cerf won the Miss France 2015 beauty contest on December 6, 2014 in Orleans. (Photo by Guillaume Souvant/AFP Photo)

An immigrant from Mali rests at the Greek-Macedonian border before an attempt to flee to Macedonia May 13, 2015 village of Idomeni in Kilkis prefecture May 13, 2015. Hundreds of mostly Afghan, Syrian, and African immigrants cross daily from Greece into Macedonia on their way to northern European countries; most of them are turned back by Macedonian border guards. (Photo by Yannis Behrakis/Reuters)

Vanessa, thirty-five, had three children with an abusive husband. She “lost her mind, started doing heroin”, after losing the children, who were taken away and given to her mother. The drugs led to homelessness and prostitution. She grew up on Arthur Avenue in the Bronx, but now spends her time in Hunts Point, “trying to survive everyday. Just doing whatever it takes”.