“Cockayne syndrome (also called Weber-Cockayne syndrome, or Neill-Dingwall Syndrome) is a rare autosomal recessive congenital disorder characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging. Hearing loss and eye abnormalities (pigmentary retinopathy) are other common features, but problems with any or all of the internal organs are possible. It is associated with a group of disorders called leukodystrophies. The underlying disorder is a defect in a DNA repair mechanism. It is named after English physician Edward Alfred Cockayne (1880–1956)”. – Wikipedia

Photo: Mother of 12-year-old Chinese girl Sun Yangyang suffering from Cockayne syndrome, tends her at the First Affiliated Hospital of Jilin University on November 11, 2006 in Changchun of Jilin Province, China. The disease results in the senile appearance of Yangyang and also causes eyesight, hearing weakness and other problems. Doctors failed to cure the girl... (Photo by China Photos/Getty Images)

“Lombard Street is an east-west street in San Francisco, California. Lombard Street is best known for the one-way section on Russian Hill between Hyde and Leavenworth Streets, in which the roadway has eight sharp turns (or switchbacks) that have earned the street the distinction of being the crookedest street in the world”. – Wikipedia

Photo: A single car drives down a typically crowded Lombard Street, San Francisco's crooked street, April 29, 2003 in San Francisco. (Photo by Justin Sullivan/Getty Images)

The waning moon sets behind leafless sumac trees on a crisp, clear morning, Thursday, December 15, 2016, in Portland, Maine. Much of the northern Mid-Atlantic and Northeast will stay cold for the next couple of days as the arctic air remains stuck over the northern Appalachians, the National Weather Service said. (Photo by Robert F. Bukaty/AP Photo)

People and sea-gulls bathe in the sea as the sun goes up with red colors in Stralsund close to the baltic sea island of Rügen, on early November 23, 2016. (Photo by Stefan Sauer/AFP Photo/DPA)

Cars drive under a rainbow near Bad Langensalza, Germany, Wednesday, November 2, 2016. (Photo by Jens Meyer/AP Photo)

A group of colorful row houses are reflected on to the top of a black car parked on 3600 block of N street in the Georgetown section of Washington DC, February 16, 2017. (Photo by John McDonnell/The Washington Post)

A woman plays with her three dogs at the beach after sunset in Del Mar, California, USA on November 10, 2017. (Photo by Mike Blake/Reuters)

One of the last incoming trains arrives outside the main train station after Deutsche Bahn cancelled all train traffic in Germany due to heavy storms, Frankfurt, Germany, Thursday, January 18, 2018. (Photo by Michael Probst/AP Photo)