Wellcome trust employee Zoe Middleton poses behind an artwork entitled “My Soul” by Katharine Dowson, which consists of a laser etched lead chrystal glass formation in the shape of a brain, and was created using the artists own MRI Scan, at Wellcome Collection on March 27, 2012 in London, England. (Photo by Dan Kitwood/Getty Images)

Since its unveiling in 2006 this masterpiece created by Frank Gehry to house the Hotel Marqués de Riscal has become a highly sought after contemporary, luxury retreat. Design, art, gastronomy, wine and the lush landscape all combine to create a memorable sojourn.

A model presents a creation by Chinese designer Hu Sheguang from Sheguang Hu collection at China Fashion Week in Beijing, March 31, 2016. (Photo by Jason Lee/Reuters)

Model Irina Shayk and Arthur Sales present the new collection “Xti 2011-12” on March 14, 2011 in Madrid, Spain. (Photo by Carlos Alvarez/Getty Images)

Model Jennifer Hawkins showcases designs by Yeojin Bae on the catwalk at the Myer A/W 2012 Collection Launch on March 1, 2012 in Melbourne, Australia. (Photo by Scott Barbour/Getty Images)

An artwork entitled “Are you still mad at me?” by John Isaacs is displayed at the Death: A Self-portrait exhibition at the Wellcome Collection on November 14, 2012 in London, England. The exhibition showcases 300 works from a unique collection by Richard Harris, a former antique print dealer from Chicago, devoted to the iconography of death. The display highlights art works, historical artifacts, anatomical illustrations and ephemera from around the world and opens on November 15, 2012 until February 24, 2013. (Photo by Peter Macdiarmid)

Holly Spring, a New Zealand photographer, says she is inspired by her daughter Violet, who was born with multiple ailments; Hirschsprung’s Disease, a blockage of the large intestine and Symbrachydactyly, a limb abnormality. The series was designed to show her daughter that she “can live a life without obstacles”. (Photo by Holly Spring)

A model backstage before the Issa London runway show at London Fashion Week Spring/Summer 2012 on September 17, 2011 in London, England. (Photo by Tim Whitby/Getty Images)