In the spring of 1965, within weeks of 3,500 American Marines arriving in Vietnam, a 39-year-old Briton named Larry Burrows began work on a feature for LIFE magazine, chronicling the day-to-day experience of U.S. troops on the ground – and in the air – in the midst of the rapidly widening war. The photographs in this gallery focus on a calamitous March 31, 1965, helicopter mission; Burrows’ “report from Da Nang”, featuring his pictures and his personal account of the harrowing operation, was published two weeks later as a now-famous cover story in the April 16, 1965, issue of LIFE.

Photo: Man your battle stations: The crew chief of helicopter Yankee Papa 13, lance corporal James C. Farley, mans an M-60 machine gun during a mission near Da Nang, Vietnam on March 31, 1965. (Photo by Larry Burrows/Time & Life Pictures)

Actor George Clooney from the film “Ides Of March” arrives at the Hotel Excelsior during the 68th Venice Film Festival on August 31, 2011 in Venice, Italy. (Photo by Gareth Cattermole/Getty Images)

Carlos Melendez prepares to feed his pet squirrel “Colita” in downtown San Salvador January 29, 2015. (Photo by Jose Cabezas/Reuters)

Pakistani female police commandos attend a training session in Nowshera, near Peshawar Pakistan, Wednesday, February 11, 2015. Authorities formed a Special Combat Unit after Taliban militants stormed a Peshawar school on Dec. 16, 2014 and massacred 150 children and teachers. (Photo by Mohammad Sajjad/AP Photo)

Jorge, an immigrant from Mexico, dressed as the Sesame Street character Elmo rests in Times Square, New York July 29, 2014. Elmo and Cookie Monster have long delighted young viewers on TV's “Sesame Street”, but the recent antics of New York street performers dressed as the beloved characters have drawn the ire of city officials and now the show's producers. Sesame Workshop, which owns the rights to Big Bird, Ernie and the assorted puppet monsters on the 45-year-old program, said on July 29, 2014 it was drafting plans to stop performers who dress up as the characters from appearing in Times Square, where they pose for photos with tourists and then demand tips. (Photo by Eduardo Munoz/Reuters)

Baloo (R), a North American Black Bear, rubs snouts with his companion Shere Hkhan, a Bengal tiger, inside their shared enclosure at Noah's Ark animal sanctuary in Locust Grove, Georgia, USA, 28 August 2014. According to the facility, the pair and a lion named Leo, were confiscated at a young age from a drug dealer's basement in Atlanta, Georgia. Noah's Ark cares for about 100 different species of animals on a 250 acre farm since 1990. (Photo by Erik S. Lesser/EPA)

Actress Penelope Cruz attends a photocall promoting the film “Chromophobia” at the Palais during the 58th International Cannes Film Festival May 21, 2005 in Cannes, France. (Photo by M. J. Kim/Getty Images)

“A huge wasp measuring 2.5 inches in length, visiting the banana tree in my front yard”. (Photo and comment by John Matzick, USA/2013 Sony World Photography Awards via The Atlantic)