“Cockayne syndrome (also called Weber-Cockayne syndrome, or Neill-Dingwall Syndrome) is a rare autosomal recessive congenital disorder characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging. Hearing loss and eye abnormalities (pigmentary retinopathy) are other common features, but problems with any or all of the internal organs are possible. It is associated with a group of disorders called leukodystrophies. The underlying disorder is a defect in a DNA repair mechanism. It is named after English physician Edward Alfred Cockayne (1880–1956)”. – Wikipedia

Photo: Mother of 12-year-old Chinese girl Sun Yangyang suffering from Cockayne syndrome, tends her at the First Affiliated Hospital of Jilin University on November 11, 2006 in Changchun of Jilin Province, China. The disease results in the senile appearance of Yangyang and also causes eyesight, hearing weakness and other problems. Doctors failed to cure the girl... (Photo by China Photos/Getty Images)

“Lombard Street is an east-west street in San Francisco, California. Lombard Street is best known for the one-way section on Russian Hill between Hyde and Leavenworth Streets, in which the roadway has eight sharp turns (or switchbacks) that have earned the street the distinction of being the crookedest street in the world”. – Wikipedia

Photo: A single car drives down a typically crowded Lombard Street, San Francisco's crooked street, April 29, 2003 in San Francisco. (Photo by Justin Sullivan/Getty Images)

“Annelies Marie “Anne” Frank (12 June 1929 – early March 1945) was one of the most renowned and most discussed Jewish victims of the Holocaust. Acknowledged for the quality of her writing, her diary has become one of the world's most widely read books, and has been the basis for several plays and films”. – Wikipedia

Photo: Childrens watch the wax figure of Anne Frank and their hideout reconstruction at Madame Tussauds on March 9, 2012 in Berlin, Germany. (Photo by Andreas Rentz/Getty Images)

Indian forest officials and police personnel try to chase away a wild male elephant at Hengrabari area in Guwahati on April 30, 2019. The elephant came down from Amchang Wildlife Sanctuary in search of food and later forest official tranquillized it, local media reported. As the pressure of population pushes human habitation closer to forests incidents of wild animals straying into cities is increasingly reported. (Photo by Biju Boro/AFP Photo)

Moruti Mthalane of South Africa is punched by Masayuki Kuroda of Japan during their IBF flyweight title boxing bout in Tokyo on May 13, 2019. (Photo by Charly Triballeau/AFP Photo)

Sea of clouds is seen after a rainfall at the Huangshan Mountain scenic spot on April 10, 2019 in Huangshan, Anhui Province of China. (Photo by Fang Lihua/Qianlong.com/VCG via Getty Images)

School children wear face masks as they take part in an awareness rally against the use of tobacco on “World No Tobacco Day” in Kolkata on May 31, 2022. (Photo by Dibyangshu Sarkar/AFP Photo)

Natural world and wildlife shortlist. Lop Buri in Thailand is home to hundreds of macaques, which local residents consider to be disciples of the Hindu god Hanuman. While some people love them, others fear or even hate them. Despite the inconvenience they often cause, the macaques are generally respected and considered sacred. (Photo by Joan de la Malla/Sony World Photography Awards)