“Nicholas II (Russian: Николай II, Николай Александрович Романов, tr. Nikolay II, Nikolay Alexandrovich Romanov) (18 May [O.S. 6 May] 1868 – 17 July 1918) was the last Emperor of Russia, Grand Prince of Finland, and titular King of Poland. His official title was Nicholas II, Emperor and Autocrat of All the Russias and he is known as Saint Nicholas the Passion-Bearer by the Russian Orthodox Church. Nicholas II, his wife, his son, his four daughters, the family's medical doctor, the Tsar's valet, the Empress' lady-in-waiting and the family's cook were murdered in the same room by the Bolsheviks on the night of 16/17 July 1918”. – Wikipedia

Photo: Tsar Nicholas II (1868–1918) with his wife. (Photo by W. & D. Downey/Getty Images). Circa 1900

“Cockayne syndrome (also called Weber-Cockayne syndrome, or Neill-Dingwall Syndrome) is a rare autosomal recessive congenital disorder characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging. Hearing loss and eye abnormalities (pigmentary retinopathy) are other common features, but problems with any or all of the internal organs are possible. It is associated with a group of disorders called leukodystrophies. The underlying disorder is a defect in a DNA repair mechanism. It is named after English physician Edward Alfred Cockayne (1880–1956)”. – Wikipedia

Photo: Mother of 12-year-old Chinese girl Sun Yangyang suffering from Cockayne syndrome, tends her at the First Affiliated Hospital of Jilin University on November 11, 2006 in Changchun of Jilin Province, China. The disease results in the senile appearance of Yangyang and also causes eyesight, hearing weakness and other problems. Doctors failed to cure the girl... (Photo by China Photos/Getty Images)

A Palestinian beekeeper uses smoke to calm bees in the process of collecting honey at a farm in Rafah, in the southern Gaza Strip April 11, 2016. Rateb Samour sees 250 patients a day, whose complaints range from hair loss to cerebral palsy and cancer. He is not a doctor and has never worked in a hospital. Samour inherited the skill of bee-sting therapy from his father. From 2003 the agricultural engineer dedicated all his time to study and develop the alternative-medicine treatment of apitherapy, which uses bee-related products from honey, propolis – or bee glue used to build hives – to venom. (Photo by Suhaib Salem/Reuters)

An internally displaced woman collects water from a pond to construct a mud-house at the Aboushok camp in El Fasher, North Darfur, Sudan, November 17, 2015. The conflict in Sudan's Darfur region that erupted 12 years ago shows no sign of ending. But it hasn't stopped displaced youngsters, some of whom have spent their entire lives in refugee camps, from dreaming big. Twelve children aged 12 explain their hopes and dreams for the future; ambitions include becoming a doctor, an engineer and a teacher. (Photo by Mohamed Nureldin Abdallah/Reuters)

Chinese woman Zhang Jing, known as the “Ugly Girl” smiles after doctors removed the stitches from her fourth session of cosmetic surgery at a hospital on March 23, 2005 in Shanghai, China. Zhang Jing, 26 years old, from Tianjin Municipality, was forced to leave school because her classmates sneered at her appearance during her teenage years. After leaving junior high school, Zhang found herself still unacceptable by society, she struggled to look for a job, but was turned down by one thousand job applications in ten years. Zhang's story was widely reported by the media in 2003, this helped her find a job and get three chances of free plastic surgery. (Photo by China Photos/Getty Images)

Takeoka Chisaka, Hiroshima, Japan. “One morning in August 1945, I was walking home from the night shift at a factory in Hiroshima. As I reached my door, there was a huge explosion. When I came to, my head was bleeding and I had been blasted 30m away. The atomic bomb had detonated. When I found my mother, her eyes were badly burned. A doctor said they had to come out, but he didn’t have the proper tools so used a knife instead. It was hellish. I became a peace-worker after the war. In the 1960s, at a meeting at the UN, I met one of the people who created the atomic bomb. He apologised”. (Photo and caption by Sasha Maslov)

Mexican wrestler known as Mini Psycho walks inside the Basilica of Our Lady Guadalupe during the annual pilgrimage in Mexico City, Mexico August 25, 2016. (Photo by Carlos Jasso/Reuters)

Keep your eyes peeled: A Chinese teenager slipped and stabbed himself in the face with a 7cm knife while peeling an apple. Ren Hanzhi's father recalled: “He was walking to the sofa while peeling the apple. Suddenly he slipped down and his face hit onto the sharp knife. I dared not pull out the knife as my son was screaming”. The nearest hospital referred the 13-year-old to a larger unit. Chief surgeon Peng Liwei, who operated to remove the knife, commented: “It's shocking. The knife, which is more than 20cm long, penetrated 7cm into his face. The surgery was successful and the patient could recover fully in around a month”. (Photo by Rex Features)