“Cockayne syndrome (also called Weber-Cockayne syndrome, or Neill-Dingwall Syndrome) is a rare autosomal recessive congenital disorder characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging. Hearing loss and eye abnormalities (pigmentary retinopathy) are other common features, but problems with any or all of the internal organs are possible. It is associated with a group of disorders called leukodystrophies. The underlying disorder is a defect in a DNA repair mechanism. It is named after English physician Edward Alfred Cockayne (1880–1956)”. – Wikipedia

Photo: Mother of 12-year-old Chinese girl Sun Yangyang suffering from Cockayne syndrome, tends her at the First Affiliated Hospital of Jilin University on November 11, 2006 in Changchun of Jilin Province, China. The disease results in the senile appearance of Yangyang and also causes eyesight, hearing weakness and other problems. Doctors failed to cure the girl... (Photo by China Photos/Getty Images)

“Lombard Street is an east-west street in San Francisco, California. Lombard Street is best known for the one-way section on Russian Hill between Hyde and Leavenworth Streets, in which the roadway has eight sharp turns (or switchbacks) that have earned the street the distinction of being the crookedest street in the world”. – Wikipedia

Photo: A single car drives down a typically crowded Lombard Street, San Francisco's crooked street, April 29, 2003 in San Francisco. (Photo by Justin Sullivan/Getty Images)

“Annelies Marie “Anne” Frank (12 June 1929 – early March 1945) was one of the most renowned and most discussed Jewish victims of the Holocaust. Acknowledged for the quality of her writing, her diary has become one of the world's most widely read books, and has been the basis for several plays and films”. – Wikipedia

Photo: Childrens watch the wax figure of Anne Frank and their hideout reconstruction at Madame Tussauds on March 9, 2012 in Berlin, Germany. (Photo by Andreas Rentz/Getty Images)

A woman plays with her three dogs at the beach after sunset in Del Mar, California, USA on November 10, 2017. (Photo by Mike Blake/Reuters)

One of the last incoming trains arrives outside the main train station after Deutsche Bahn cancelled all train traffic in Germany due to heavy storms, Frankfurt, Germany, Thursday, January 18, 2018. (Photo by Michael Probst/AP Photo)

In this Thursday, May 31, 2018 photo, a temporary worker using a lantern collects white asparagus from a field in Caparroso, around 85 km (52 miles) from Pamplona, northern Spain. Dubbed the “white gold” of these northern Spanish farms because of their color and the high price they fetch in markets and restaurants around the world, the stringy delicacy is planted every fall and picked each year between April and June, at the height of the spring. (Photo by Alvaro Barrientos/AP Photo)

Cooler temperatures begin this week as a polar vortex brings much colder conditions with the chance of snow for Snowdonia, Ogwen Valley, North Wales on 22nd October 2018. The Ogwen Valley and Tryfan Mountain looking splendid in the Autumn sunrise. (Photo by DGDImages/Alamy Live News)

A group of colorful row houses are reflected on to the top of a black car parked on 3600 block of N street in the Georgetown section of Washington DC, February 16, 2017. (Photo by John McDonnell/The Washington Post)